Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform
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چکیده
منابع مشابه
Targeting CD123 in acute myeloid leukemia using a T-cell-directed dual-affinity retargeting platform.
T-cell-directed killing of tumor cells using bispecific antibodies is a promising approach for the treatment of hematologic malignancies. Here we describe our preclinical work with a dual-affinity retargeting (DART) molecule generated from antibodies to CD3 and CD123, designed to redirect T cells against acute myeloid leukemia blasts. The CD3×CD123 DART (also referred to as MGD006/S80880) consi...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-05-575704